GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THYM | cis | rs9309473 | 1 | rs2421555 | chr2:73816955 | ALMS1P | chr2:73872046-73912692:+ | 0.58 | 4.7 | 8.77E-6 | Metabolite levels |
| THYM | cis | rs9362426 | 1 | rs242271 | chr6:88082029 | C6orf164 | chr6:88032306-88109459:+ | -0.52 | -4.99 | 2.7E-6 | Depressive episodes in bipolar disorder |
| THYM | cis | rs10461617 | 1 | rs2432195 | chr5:56120413 | C5orf35 | chr5:56205103-56213010:+ | 0.75 | 9.44 | 2.59E-15 | Type 2 diabetes |
| THYM | cis | rs2251844 | 1 | rs2447196 | chr15:43893818 | ADAL | chr15:43622872-43646094:+ | 0.49 | 4.25 | 4.9E-5 | Tumor biomarkers |
| THYM | cis | rs2251844 | 1 | rs2447208 | chr15:43933895 | ADAL | chr15:43622872-43646094:+ | -0.53 | -4.45 | 2.33E-5 | Tumor biomarkers |
| THYM | cis | rs2251844 | 1 | rs2447208 | chr15:43933895 | CATSPER2 | chr15:43922774-43959900:- | -0.65 | -4.98 | 2.88E-6 | Tumor biomarkers |
| THYM | cis | rs2251844 | 1 | rs2447211 | chr15:43936351 | ADAL | chr15:43622872-43646094:+ | -0.51 | -4.38 | 3.06E-5 | Tumor biomarkers |
| THYM | cis | rs9369898 | 1 | rs2448704 | chr6:49453672 | CENPQ | chr6:49431096-49460820:+ | 0.3 | 5.69 | 1.37E-7 | Homocysteine levels |
| THYM | cis | rs9473555 | 1 | rs2448707 | chr6:49446951 | CENPQ | chr6:49431096-49460820:+ | 0.24 | 4.35 | 3.42E-5 | Folate pathway vitamin levels |
| THYM | cis | rs9473555 | 1 | rs2448707 | chr6:49446951 | MUT | chr6:49398994-49431031:- | -0.28 | -4.29 | 4.25E-5 | Folate pathway vitamin levels |
| THYM | cis | rs2243480 | 1 | rs2460422 | chr7:65601505 | CCT6P1 | chr7:65216092-65228661:+ | 0.64 | 5.31 | 7.1E-7 | Diabetic kidney disease |
| THYM | cis | rs2243480 | 1 | rs2462569 | chr7:65474846 | CCT6P1 | chr7:65216092-65228661:+ | -0.6 | -4.98 | 2.86E-6 | Diabetic kidney disease |
| THYM | cis | rs11825709 | 1 | rs2462756 | chr11:93758301 | HEPHL1 | chr11:93754378-93847374:+ | -0.94 | -4.25 | 4.93E-5 | Obesity-related traits |
| THYM | cis | rs2463822 | 1 | rs2463820 | chr11:62112290 | ASRGL1 | chr11:62104774-62160885:+ | 0.55 | 5.39 | 5.18E-7 | Chronic obstructive pulmonary disease-related biomarkers |
| THYM | cis | rs2463822 | 1 | rs2463821 | chr11:62111662 | ASRGL1 | chr11:62104774-62160885:+ | 0.55 | 5.39 | 5.18E-7 | Chronic obstructive pulmonary disease-related biomarkers |